Normal nonspecific bronchial reactivity excludes occupational asthma?
نویسندگان
چکیده
منابع مشابه
Predictive value of nonspecific bronchial responsiveness in occupational asthma.
BACKGROUND The diagnosis of occupational asthma (OA) can be challenging and needs a stepwise approach. However, the predictive value of the methacholine challenge has never been addressed specifically in this context. OBJECTIVE We sought to evaluate the sensitivity, specificity, and positive and negative predictive values of the methacholine challenge in OA. METHODS A Canadian database was ...
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We investigated 654 subjects of a small Lombardy (Italy) town between 15 and 64 years of age who were representative of the general population. By clinical examination, the sample included 535 normal subjects (164 normal smokers, 341 normal nonsmokers, 30 normal subjects with acute upper respiratory illness within 30 days before the challenge), 50 with chronic bronchitis, 26 with asthma, and 43...
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There is evidence that bronchial responsiveness to allergen is quantitatively correlated with bronchial responsiveness to nonspecific stimuli in subjects with allergic asthma. This association has been questioned in occupational asthma due to low molecular weight substances. It was the aim of this study to assess the quantitative association of bronchial responsiveness to methacholine (MCh) and...
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АСТМА ТА АЛЕРГІЯ, No 1 • 2015 Bronchial asthma (BA) and recurrent bronchitis occupy the leading place among chronic and recurrent respiratory diseases in children age. Special importance of problem of these diseases gets in view of the provisions that recurrent respiratory diseases in children is the debut of chronic bronchopulmonary pathology of adult period of life [1, 16]. One of the importa...
متن کاملEffect of oral lithium on bronchial reactivity in asthma.
1. Recognition that inositol phospholipid-derived second messengers are involved in the initiation and maintenance of airway smooth muscle contraction raises the possibility of new therapeutic approaches to the treatment of asthma. We anticipated that lithium, through its effects on cell signal transduction and ion-transport pathways, would be likely to protect the airways against constrictor s...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2016
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2016.07.004